損害記憶力
損害記憶力，增加老年時患阿爾茲海默症患病率。
美國心臟協會通過對1000名年齡在45歲以下的健康男性的調查發現，大量攝入反式脂肪酸的受試者，在單詞記憶測試方面成績最差。即使在考慮年齡、教育水平和抑鬱症等因素後，這一關聯仍然存在。
研究的領導者、加州大學聖地亞哥醫學院的碧翠斯•戈洛姆(Beatrice Golomb)博士表示，“反式脂肪酸確實可以延長食物的保質期，但同時人類健康的‘保質期’卻隨之縮短。”
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